Drugs Associated with Stevens-Johnson Syndrome
Stevens-Johnson Syndrome as a Severe Reaction to Medication
Stevens-Johnson Syndrome (SJS) is a form of toxic epidermal necrolysis (TEN) that involves a severe adverse reaction of skin and mucous membranes following the use of associated over-the-counter and prescription medications. SJS can lead to flu-like symptoms followed by a spreading red/purple rash and blisters that eventually cause the top layer of skin to die and shed. If this disorder is not treated at the onset, it may lead to extremely serious conditions such as:
- hearing loss
- organ failure
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Medications Associated with Stevens-Johnson Syndrome
SJS/TEN can occur after taking medications such as:
- Acetaminophen (Tylenol®)
- Carbamazepine (mood stabilizers such as Tegretol®)
- Celebrex® or other Cox-2 inhibitors
- Dilantin® and Phenytoin®
- Ibuprofen (Advil® and Motrin®)
- Nonsteroidal anti-inflammatory drugs (Daypro®, etc.)
- sulfa antibiotics
Treatment often involves hospitalization in burn centers or debridement (surgical removal of damaged tissue). Individuals with SJS/TEN can take weeks or even months to recover depending upon the severity of the condition.
Consult a medical professional before stopping or changing any medication.