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Case Overview
Many people have turned to the increasingly popular semaglutide drug Ozempic® as a way to lose weight. This drug mimics hormones that reduce appetite and moderate insulin release. However, many expected and unexpected risks are associated with using Ozempic, and these risks can vary in severity.
Key takeaways about Ozempic side effects
- Patients should be aware that Ozempic has both off-label and on-label side effects that range in severity.
- Off-label side effects include, but are not limited to, vision loss, stomach paralysis and gastroenteritis.
- On-label side effects include hypoglycemia, pancreatitis and thyroid tumors.
Unexpected Ozempic weight loss side effects
Ozempic is a GLP-1 agonist prescription medication manufactured by Novo Nordisk. It was approved by the U.S. Food and Drug Administration (FDA) in 2017. Also known by its generic name, semaglutide, this Type 2 diabetes drug, which at times is prescribed off-label for weight loss, works by reducing appetite, sugar levels and glucose production, similar to its sister drug, Wegovy®.
Ozempic manufacturers disclosed some side effects on the medication guide and prescribing information. However, some reports of severe gastrointestinal events and other health problems were not included on the warning label. People are filing Ozempic lawsuits that claim Novo Nordisk knew or should have known about the risk of severe side effects like gastroparesis, gastroenteritis, intestinal blockage, blood clots and other severe health problems but failed to warn users.
Vision changes and loss
NAION (nonarteritic anterior ischemic optic neuropathy) is a condition where the arteries in the optic nerve head become inflamed. The inflammation may impact a person’s ability to see, potentially leading to blindness. For people above the age of 50, NAION is the most common reason for optic nerve damage.
A 2024 study of more than 16,000 patients found that using semaglutide drugs like Wegovy or Ozempic was associated with increased diagnoses of NAION. The study looked at individuals taking semaglutide for weight loss or diabetes management. The increased risk was consistent among all users.
Ozempic has a warning on its label for diabetic retinopathy, a type of vision loss associated with diabetes. Because NAION and diabetic retinopathy may have similar symptoms, misdiagnoses are possible. If you or a loved one have experienced vision changes after taking Ozempic or other semaglutide drugs, consult with your doctor about the possibility of NAION.
Stomach paralysis aka gastroparesis (not on warning label)
Also known as stomach paralysis, gastroparesis slows down the movement of stomach muscles, preventing the stomach from emptying properly. This can lead to many debilitating symptoms and alleged Ozempic side effects, including:
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Gastroparesis can be a very serious medical condition for which there is no cure. Motley Rice is currently representing a woman who developed severe gastroparesis after taking semaglutide medication. This ultimately led to painful cramping, nausea and vomiting that required hospitalization.
Learn more about how to file an Ozempic lawsuit for gastroparesis.
Gastroenteritis (not on warning label)
Gastroenteritis occurs when the intestines and stomach become inflamed. Gastroenteritis, when viral, is also commonly referred to as the stomach flu. However, gastroenteritis may also be caused by certain types of medication. Some of the most common symptoms associated with gastroenteritis allegedly caused by Ozempic include:
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Gastroenteritis can be far more severe than mild nausea and vomiting. The side effects of dehydration may require hospitalization, and continued symptoms can make it difficult to complete daily tasks.
Ileus (intestinal blockages)(added to warning label in September 2023)
Ozempic consumers have also reported obstructions and intestinal blockages that began after starting the medication for diabetes or weight loss. Potential signs and symptoms associated with intestinal blockages allegedly linked to Ozempic include:
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Intestinal blockages may initially manifest with mild symptoms. However, without treatment, blockages can quickly become serious medical events. Intestinal obstructions and blockages are considered medical emergencies that must be taken seriously. Failure to treat an intestinal blockage quickly enough could result in infection, intestinal perforation, or even death.
Muscle loss
Many consumers are unaware that taking Ozempic could lead to extreme muscle loss. This can occur when people lose weight quickly without maintaining exercise habits and a balanced diet. Also known as sarcopenia, severe muscle loss can lead to death. Some common symptoms of muscle loss could include:
- Decrease in muscle mass
- Difficulty performing daily activities
- Falls
- Loss of stamina
- Poor balance
- Trouble climbing stairs
- Walking slowly
Sarcopenia can also lead to other severe side effects and conditions, including insulin resistance, reduced bone density and lowered metabolism.
Other potential off-label side effects of Ozempic
Consumers have reported many other label side effects after starting Ozempic or Wegovy, including:
- Malnutrition: You can become malnourished when your body is deprived of nutrients, minerals and vitamins. Symptoms of malnutrition include skin pigmentation changes, soft bones, bleeding gums, pale skin, rashes, thinning hair, achy joints and easy bruising.
- Blood clots and deep vein thrombosis: Blood clots are coagulated clumps of blood. A 2021 study reported that Ozempic use increased the risk of deep vein thrombosis, a condition caused by blood clotting deep in the body. DVT can be a very serious condition and can lead to pulmonary embolism.
Anyone taking Ozempic, Rybelsus®, Mounjaro™ or any semaglutide drug should not hesitate to contact their physician if they experience new or worsening side effects. It may also be in your best interests to connect with an Ozempic lawyer to explore your legal options.
Unexpected Ozempic side effects lead to lawsuits
The side effects not included on the Ozempic warning label are alarming. Thousands of people have allegedly been harmed, and records indicate manufacturer Novo Nordisk knew about these risks. Ozempic’s predecessor, Saxenda, caused similar side effects and was approved in 2014.
As of August 2024, tens of thousands of reports of health problems after taking Ozempic have been filed with the FDA Adverse Event Reporting System. Some noteworthy lawsuits include the following people affected by Ozempic:
- A 52-year-old woman taking weekly semaglutide injections experienced gastroparesis symptoms within one month of starting Ozempic.
- A 57-year-old woman taking dulaglutide injections every week for over a year began experiencing nausea, vomiting and bloating associated with delayed gastric emptying within three months of starting the prescription medication. These side effects improved when the patient stopped taking the dulaglutide.
- A 39-year-old woman needed to be hospitalized with significant gastrointestinal issues that have continued to affect her life even after she stopped taking Ozempic.
Patients suffering extreme side effects associated with Ozempic use have said the symptoms made it difficult or impossible to complete daily tasks or live life as they did before beginning Ozempic.
Legal action against Novo Nordisk may offer justice and compensation for affected people. Compensation can help people cover financial losses, medical expenses and other relevant economic and non-economic damages.
Consult our Ozempic attorneys
Submit our quick contact form or call our office at 1.800.768.4026 to learn more or discuss a potential Ozempic lawsuit.
On-label Ozempic side effects
Like any prescription medication, Ozempic has many restrictions, precautions and side effects listed on the label. Some of the most notable warnings and precautions include organ injuries and tumors.
- Acute kidney injury: This condition may also be called acute renal failure. It can occur when the buildup of waste makes it difficult for your kidneys to maintain balance. Symptoms may include reduced urine output, swelling, seizures and coma.
- Diabetic retinopathy: This eye condition can cause blindness and vision loss in people with diabetes. Diabetic retinopathy can lead to other serious conditions affecting the eyes.
- Gallbladder disease: Gallbladder disease describes any blockage or infection in the bile duct that backs up into your gallbladder. It can affect other digestive system organs as well. There are several types of gallbladder disease. Common symptoms associated with gallbladder disease include yellowing of the skin (jaundice), abdominal pain, fever, nausea and vomiting. (Added to warning label in March 2022)
- Hypoglycemia: This condition means your blood sugar levels are lower than the standard range. Symptoms might include irritability, shakiness, illness, nausea or hunger, rapid heartbeat, sweating, lightheadedness and headache. Worsening symptoms can include slurred speech, blurred vision and seizures.
- Pancreatitis: Pancreatitis occurs when enzymes or digestive juices attack the pancreas, causing inflammation. Pancreatitis symptoms often include fever, nausea, severe abdominal pain that worsens after eating, lowered blood pressure, jaundice and fluid buildup.
- Thyroid tumors: Medullary thyroid cancer (MTC) forms inside the medulla or thyroid gland. Symptoms of MTC often include enlarged glands, difficulty breathing or swallowing and changes in thyroid activity.
Adverse reactions
The most common adverse reactions reported on Ozempic’s warning label include:
- Abdominal pain
- Constipation
- Diarrhea
- Nausea and vomiting
If you are currently taking Ozempic or any other semaglutide drug and are experiencing new or worsening side effects, consult your doctor as soon as possible. Medical treatment could reduce the severity of the side effects, but some Ozempic users find their symptoms continue even after they stop taking the drug.
Frequently asked questions about Ozempic side effects
What are the side effects of Ozempic?
There are many on-label and alleged off-label side effects of Ozempic use. Advertised side effects associated with Ozempic include nausea, constipation, organ injuries and thyroid tumors. Possible health problems not included on Ozempic’s warning label include gastroparesis, gastroenteritis, intestinal blockages, blood clots, pancreatic cancer and intraoperative pulmonary aspiration.
What are the most common side effects of Ozempic?
There are several side effects included on Ozempic labels. Some of the most common side effects of Ozempic include abdominal pain, constipation, diarrhea, nausea and vomiting. However, several more severe side effects have also been associated with Ozempic. Discuss all potential reactions with your doctor before taking Ozempic.
How long do Ozempic side effects last?
The side effects of Ozempic can significantly impact daily life. People experiencing mild symptoms may see these resolved after a few days or weeks. However, Ozempic users experiencing severe side effects may find that these symptoms last significantly longer or become a regular part of their daily lives. Severe side effects may also be life threatening.
Do Ozempic side effects go away?
If you are experiencing side effects related to Ozempic, they may initially be mild. These mild side effects may resolve in several days or weeks but may continue with ongoing use of Ozempic or Wegovy. If you experience on- or off-label side effects that can significantly impact your life, talk with your doctor and seek medical attention.
Our medical drug litigation experience
Our law firm has years of experience representing the interests of patients who became seriously ill and endured debilitating side effects associated with prescribed medications. We now represent Wegovy and Ozempic patients. If you or someone you love experienced severe symptoms related to the use of these diabetes and weight loss drugs, our personal injury attorneys may be able to help. We have the knowledge and resources to help you demand justice. Our team can help you:
- Investigate whether Ozempic could be the cause of your vision changes, gastroparesis, intestinal blockages or other side effects
- Review whether Novo Nordisk failed to warn you about the potential off-label side effects adequately
- Help build and file your case if you qualify
Read more on our medical drug experience.
If you are currently taking Wegovy or Ozempic, consult your physician before you stop taking the prescription medication. Without your physician's instruction, discontinuing these medications could result in worsening illness, injury, or death. Ozempic Rybelsus, Mounjaro and Wegovy remain approved by the U.S. Food and Drug Administration.
Key takeaways about Ozempic side effects
Unexpected Ozempic weight loss side effects
On-label Ozempic side effects
Frequently asked questions about Ozempic side effects
Our medical drug litigation experience
- Sources
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- Cleveland Clinic. Medullary Thyroid Cancer (MTC).
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- Healthline. Ozempic Can Cause Major Loss of Muscle Mass and Reduce Bone Density
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